Opportunità di Lavoro

Network Italiano per la Bioterapia dei Tumori


RESEARCH POSITION
We are looking for a highly motivated candidate to work on myeloid cells, cancer and immunotherapy.

Expertize in cellular and molecular immunology would be an advantage. The funded project aims to understand the mechanisms that drive pro-tumoral reprogramming of myeloid cells during disease progression and to understand the role of the tumor microenvironment in this process.
The effects of neoplastic growth on myelopoiesis and on the generation of immunosuppressive myeloid populations (tumor-associated macrophages and myeloid-derived suppressor cells, in particular) will be investigated.

These objectives will be achieved using approcches of integrated metabolomics, functional genomics and multiparametric flow cytometry to evaluate mouse models of genetically-driven cancers, chemically-induced and transplantable cancers. The identified mechanisms will be validated in cancer patients. Bioinformatics knowledge is appreciated.
The candidate should have successfully completed a PhD in immunology (or a field relevant to the immunobiology of cancer). English fluency and computer literacy area a must. Research activity will be based at the Laboratory of Molecular Immunology, Department of Inflammation and Immunity, Humanitas Clinical and Research Center, Rozzano, Milan.


Please send your CV to:
Antonio Sica
Professor of General Pathology, University of Eastern Piedmont and head Laboratory of Molecular Immunology, Humanitas Clinical and Research Center, via Sardegna 7, 20090, Pieve Emanuele (Rozzano, Milano). tel +390282245111. Email: antonio.sica@humanitasresearch.it


Postdoctoral fellow
The Chair for Functional Immune Cell Modulation at RCI, Prof. Luca Gattinoni is recruiting a highly motivated and interactive Postdoctoral fellow

The RCI - Regensburg Center for Interventional Immunology (foundation under public law) is a novel biomedical research center focusing on translational immunology in the fields of cancer immunotherapy, transplant rejection and autoimmunity. The objective of the RCI is to develop effective cellular immunotherapies in these areas.

The Chair for Functional Immune Cell Modulation at RCI, Prof. Luca Gattinoni is recruiting a highly motivated and interactive
Postdoctoral fellow (all gender), reference number LG-2019-6
to study the molecular and metabolic mechanisms regulating T cell differentiation and memory formation. The position is initially limited to two years with the possibility to be continued and is remunerated on the TV-L salary scale (TV-L EG 13).

Projects will focus on the regulation of T cell self-renewal and multipotency by transcription factors, microRNAs and metabolic enzymes. Findings emerging from these studies will be used to enhance the efficacy of cancer immunotherapies based on the adoptive transfer of CAR/TCR-engineered T cells.
Interested candidates must have a doctoral degree with less than five years of relevant postdoctoral experience, and have a background in immunology, molecular biology, biochemistry or a related discipline. Excellent publication record along with experience in mouse models will be considered as distinct advantages.

The RCI follows the goal of professional equality for all genders and therefore strongly encourages qualified women to apply. In addition, the RCI supports work-family balance.
The RCI is an equal opportunity employer and candidates with disabilities will be given preference, provided they are equally qualified.
If we have awakened your interest and you are open to new professional challenges, we would be delighted to receive an informative application from you.


Please send your full application including a statement of interest, curriculum vitae, certificates, expected availability date, a list of publications and 2-3 references by e-mail to Prof. Dr. Philipp Beckhove (bewerbungen.rci@ukr.de). Application deadline is November 15, 2019.

RCI – Regensburger Centrum für Interventionelle Immunologie
c/o Universitätsklinikum Regensburg
Franz-Josef-Strauss-Allee 11
93053 Regensburg
Germany .

For more information contact us: Prof. Luca Gattinoni (e-mail: gattinol@mail.nih.gov) or Prof. Philipp Beckhove (e-mail: beckhove@rcii.de; phone: +49 941 944 38102).
www.rcii.de


Senior Scientist
The Chair for Functional Immune Cell Modulation at RCI, Prof. Luca Gattinoni is recruiting a Senior Scientist

The RCI - Regensburg Center for Interventional Immunology (foundation under public law) is a novel biomedical research center focusing on translational immunology in the fields of cancer immunotherapy, transplant rejection and autoimmunity. The objective of the RCI is to develop effective cellular immunotherapies in these areas.

The Chair for Functional Immune Cell Modulation at RCI, Prof. Luca Gattinoni is recruiting a highly motivated and interactive
Senior Scientist (all gender), reference number LG-2019-5
with proved experience in the field of human T cell immunobiology and T cell-engineering. The position is initially limited to three years with the possibility to be continued and is remunerated on the TV-L salary scale (TV-L EG 14).

The senior scientist will be responsible for the development of clinical-grade protocols for the manufacturing of gene-engineered T cells that will be employed in Phase 1/2 clinical studies at the University Hospital Regensburg.
Projects derive from recent basic research and translational pre-clinical studies conducted at the RCI and primarily within the Department of Functional Immune Cell Modulation.
Gene manipulations encompass the modulation of transcription factors, microRNAs and metabolic checkpoints coupled with CAR and TCR platforms to functionally improve the antitumor efficacy of gene-redirected T cells.

Responsibilities include, but are not limited to:
•Perform all tasks associated with the manufacturing of clinical-grade cell products including the development of standard operating procedures (SOPs), batch records and other GMP documentation.
•Design and conduct clinical assays required to support assessment of T cell therapies.
•Successfully troubleshoot processing and equipment issues.

The ideal candidate possesses:
•PhD in Molecular Biology, Cell Biology, Immunology or a relevant discipline and 5 or more years of cGMP experience in a T cell manufacturing and biotechnology environment.
•Extensive experience in isolating, culturing human T cells.
•Extensive experience with virus-based and nonviral gene delivery platforms.
•Experience with automated processing equipment.
•Strong knowledge of cGMP regulations and experience in writing SOPs and documentation associated with clinical-grade cell manufacturing.
•Excellent communications skills, both oral and written in English.
•Strong analytical, organizational and time management skills.

The RCI follows the goal of professional equality for all genders and therefore strongly encourages qualified women to apply. In addition, the RCI supports work-family balance.

The RCI is an equal opportunity employer and candidates with disabilities will be given preference, provided they are equally qualified.

If we have awakened your interest and you are open to new professional challenges, we would be delighted to receive an informative application from you.


Please send your full application including a statement of interest, curriculum vitae, certificates, expected availability date, a list of publications and 2-3 references by e-mail to Prof. Dr. Philipp Beckhove (bewerbungen.rci@ukr.de). Application deadline is October 27th, 2019.

RCI – Regensburger Centrum für Interventionelle Immunologie
c/o Universitätsklinikum Regensburg
Franz-Josef-Strauss-Allee 11
93053 Regensburg
Germany .

For more information contact us: Prof. Luca Gattinoni (e-mail: gattinol@mail.nih.gov) or Prof. Philipp Beckhove (e-mail: beckhove@rcii.de; phone: +49 941 944 38102).
www.rcii.de


IBAN: IT18R0333201400000000961533