2017


Gabriele De Simone: Humanitas Clinical and Research Center


Martina Di Modica: Fondazione IRCCS Istituto Nazionale dei Tumori


Sara Caputo: San Raffaele


2016



Laura Conti

Laura Conti: Department of Molecular Biotechnology and Health Sciences University of Turin c/o Molecular Biotechnology Center, Laboratory of Immunology

Laura Conti graduated in Medical Biotechnology at Turin University in July 2003, and since her Bachelor and Master in Medical Biotechnology, she has always been interested in Immunology, with a special focus on autoimmune diseases and cancer. During her PhD in Immunology and Cell Biology (conducted at University of Turin from 2003 to 2007), she studied the effect of microenvironmental factors on T lymphocytes, and analyzed their role in multiple sclerosis. Since 2009 she focused mainly on tumor immunology, working in Prof. F. Cavallo’s group, conducting a study aimed at discovering new antigens expressed in ErbB2+ and triple negative breast cancer stem cells. This research led to the identification of different antigens that play key roles in cancer stem cell biology. In particular, she demonstrated that Toll-like Receptor 2 is expressed on breast cancer stem cells and promotes their self-renewal and tumorigenic and metastatic abilities, shedding new light on the controversial use of Toll-like Receptor 2 agonists in cancer immunotherapy. She also found out that the ferritin receptor Scara5 is a marker of breast cancer stem cells that can be exploited to deliver to them ferritin loaded with drugs and/or contrast agents, for both diagnostic and therapeutic purposes. Moreover, she actively contributed to the identification of xCT, the light chain of the cysteine/glutamate antiporter system xc-, as an interesting clinical target for the immunotherapy of breast cancer. She is now actively working on the set up of DNA or viral vaccination-based immunotargeting of xCT in order to find new immunotherapeutic protocols for the treatment of aggressive forms of Her2+ and triple negative breast cancers.
During her 15 years of experience in basic and translational immunology she has developed technical skills and a deep expertise in molecular and cellular immunology, with a special focus on the generation of preclinical mouse models, cytofluorimetric analysis, optical imaging and cancer stem cells. This expertise allowed her to publish 30 articles on international journals, giving her contribution to the fields of autoimmune diseases and cancer immunotherapy.


Angela Rita Elia: I.R.C.C.S. San Raffaele



Christian Hotz

Christian Hotz: BioNTech RNA Pharmaceuticals GmbH in Mainz, Germany.

Christian Hotz received his PhD on bacterial cancer therapy from the University of Würzburg, Germany in 2009. For his postdoctoral training Dr. Hotz moved to Munich, Germany and later to Fribourg, Switzerland to work on innate immune receptor signaling and the application of small molecule immune response modifiers for cancer immunotherapy. He finished his Habilitation in Immunopharmacology in 2016 and obtained the title Privat-docent from the University of Fribourg. Currently, Dr. Hotz is employed as Senior Scientist at BioNTech RNA Pharmaceuticals in Mainz, Germany. In an international collaboration project, he is responsible for the early in vivo evaluation and preclinical development of novel RNA-based agents for the immunotherapy of cancer


2015




Carla Chiarucci

Carla Chiarucci: Center for immuno-Oncology (CIO)

I received my Master Degree in Health Biology at the University of Siena in 2012. On 2013, I’ve been selected to join the Doctorate Program in Genetic Oncology and Clinical Medicine (GENOMEC) at the University of Siena, Italy. During the PhD, I’ve focused my attention on the identification of new biomarkers that could be predictive for the clinical outcome of Mesothelioma patients treated with the anti-CTLA-4 monoclonal antibody tremelimumab. I’ve had the chance to present these data at different scientific national and international meetings. I defended my PhD thesis on April 2017 at the University of Siena, Italy. Actually, I’m working as Postdoc at the Unit of Medical Oncology and Immunotherapy, Center for Immuno-Oncology, University Hospital of Siena continuing the research on mesothelioma biomarkers.


Arianna Calcinotto: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland



Corna Gianfranca

Corna Gianfranca: San Raffaele Institute

I received my Master Degree in Biology (2001) and a PhD in Experimental Pathology (2005) from the “Università degli studi di Milano”. The topic of my PhD project was role of iron in the carditoxicyty of the anticancer drug doxorubicin. During my PhD I spent almost one year at EMBL in Heidelberg (Germany). I’m currently a senior Post-Doc in the lab of Vincenzo Russo at San Raffaele Scientific Institute, working on the role of oxysterols in pancreatic neuroendocrine tumors. I was awarded by Italian Ministry of Education (2001), Ospdedale Maggiore di Milano (2006), AIRC (2007) and ENETs (2017) Fellowships.


2014



Mihaela Angelova: Division of Bioinformatics, Biocenter, Innsbruck Medical University


Diletta Di Mitri: Molecular Oncology laboratory Institute of Oncology Research (IOR) Oncology Institute of Southern Switzerland (IOSI)


Alessandra Tucitto: Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Experimental Oncology, Unit of Immunotherapy of Human Tumors


2013



Jachetti Elena

2018- present: Scientist/Junior PI. Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Research activity:  How stromal components can shape the growth and the immune-contexture in prostate cancer.

2013- 2017: Post Doctoral Fellow. Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Research activity:  Role of mast cells and extracellular matrix in prostate cancer.

2011-2013: Post Doctoral Fellow. Cellular Immunology Unit, San Raffaele Scientific Institute, Milan, Italy. Research activity: Isolation and immunological characterization of prostate cancer stem cells.

2007-2011: PhD Student. Cellular Immunology Unit, San Raffaele Scientific Institute, Milan, Italy. Research activity: Isolation and immunological characterization of prostate cancer stem cells.

2006: Fellow. Cellular Immunology Unit, San Raffaele Scientific Institute, Milan, Italy. Research activity: Development of strategies of cancer immunotherapy.

I worked on tumor microenvironment since undergraduate and PhD studies in Dr. Bellone's lab at San Raffaele Scientific Institute, Milan, Italy. During my PhD, I studied cancer stem cells-T cells interaction and tumor tolerance in prostate cancer. I also contributed to several publications in the field of tumor immunology and microenvironment. Continuing studies on prostate cancer microenvironment, on 2013 I moved for Post Doc to Dr. Colombo's lab at Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Here I have started to study the role of different stromal components in regulating prostate cancer differentiation and immune-contexture. I contributed to elucidate the dual role of Mast cells, either promoting or preventing adenocarcinoma or NE tumors, respectively. Now I am focusing on the study of molecular mechanism linking stromal composition, prostate cancer differentiation and immune contexture.


Alessia Covre

Research associate at Division of Medical Oncology and Immunotherapy Department of Oncology, University Hospital Siena.
2010-2012 “triennal fellowships 2010 – 2012 Guglielmina Lucatello e Gino Mazzega”
Co- authored of more than 15 scientific papers in microbiogy, epigenetics and cancer immunology and book chapter.

Winner of the 2013 Gianni Bonadonna Prize for new drug development in cancer


Anna Pastò

Master Degree in Medical Biotechnology – Molecular medicine with a 110/110 cum laude mark, with the thesis: ”Effects of physical inactivity on oxidative stress and muscular glutathione synthesis in vivo in human” at the University of Trieste.
PhD student at Department of Surgery, Oncology and Gastroenterology of the University of Padova under the supervision of Prof. Amadori. Topics: normal and cancer colon stem cells isolation and characterization; Notch pathway and its implication in tumor eradication.
Post Doc at Department of Surgery, Oncology and Gastroenterology of the University of Padova. Topics: ovarian cancer stem cell metabolism linked to response to anti-angiogenic therapies.


Dario Sangiolo

Current Position: Researcher at the University of Turin, Department of Oncology, IRCCS Candiolo (TO).
Qualifications: PhD in Oncology (2008);
Postgraduate Medical Oncology (2003), Graduate Medicine (1998)